Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy

doi:10.3748/wjg.v22.i30.6944

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2016; 22(30): 6944-6954
Published online Aug 14, 2016. doi: 10.3748/wjg.v22.i30.6944

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Figure 1 Signal transduction pathways controlled by the activation of epidermal growth factor receptor. Adapted from Ref. [64]. TGFα: Transforming growth factor alpha; ECF: Eosinophil chemotactic factor; HB-EGF: Heparin-binding EGF-like growth factor; NGR: Neuregulin; EGFR: Epidermal growth factor receptor; bFGF: Basic fibroblast growth factor; VEGF: Vascular endothelial growth factor; PI3K: Phosphoinositide 3-kinase; SOS: Son of sevenless homolog protein.

Citation: Lo Nigro C, Ricci V, Vivenza D, Granetto C, Fabozzi T, Miraglio E, Merlano MC. Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy. World J Gastroenterol 2016; 22(30): 6944-6954
URL: https://www.wjgnet.com/1007-9327/full/v22/i30/6944.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i30.6944