Current stage in inflammatory bowel disease: What is next?

doi:10.3748/wjg.v21.i40.11282

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Oct 28, 2015 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2015; 21(40): 11282-11303
Published online Oct 28, 2015. doi: 10.3748/wjg.v21.i40.11282

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Figure 1 Metabolism of azatioprine and 6-mercaptopurine. AZA: Azathioprine; 6-MP: 6-mercaptopurine; 6-MeMP: 6-methylmercaptopurine; 6-TU: 6-thiouric acid; 8-OH 6MP: 8-hydroxymercaptopurine; 6Me-tIMP: 6-methyl thioinosine monophosphate; 6-tIMP: 6-thioinosine monophosphate; 6-TIDP: 6-thioinosine diphosphate; 6-TITP: 6-thioinosine triphosphate; 6-MeTITP: 6-methylthioinosine triphosphate; tXMP: Thioxanthine monophosphate tGMP: Thioguanine monophosphate; tGDP: Thioguanine diphosphate; tGTP: Thioguanine triphosphate; Me-tGMP: Methylthioguanine monophosphate; Deoxy-tGTP: Deoxythioguanine triphosphate; GST: Glutathione S-transferasa; TPMT: Thipurine methyltransferase; XDH: Xanthine dehydrogenase; AO: Aldehyde oxidase; HGPRT: Hypoxanthine guanine phosphoribosyltransferase; IMPDH: Inopine monophosphate dehydrogenase; GMPS: Guanosine monophosphate synthetase; PK: Phosphokinase; rPK: Reductase phosphokinase.

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Figure 2 Algorithm of treatment for non responders to thiopurine drugs. AZA: Azathioprine; 6-MP: 6-mercaptopurine; 6-TG: 6-thioguanine; 6-MeMp: 6-methyl mercaptopurine.

Citation: Gómez-Gómez GJ, Masedo &, Yela C, Martínez-Montiel MDP, Casís B. Current stage in inflammatory bowel disease: What is next? World J Gastroenterol 2015; 21(40): 11282-11303
URL: https://www.wjgnet.com/1007-9327/full/v21/i40/11282.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i40.11282