Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn’s disease

Figure 1 Changes in oxidative stress markers before and 8 wk after starting anti-TNF-α treatment in patients with Crohn’s disease. A: d-ROM decreased significantly 8 wk after treatment; B: BAP did not change significantly after anti-TNF-α treatment; C: m-OA did not change significantly after anti-TNF-α treatment.

Figure 2 Correlation of d-ROM and m-OA with Crohn’s disease activity index. A: d-ROM showed a significant correlation with CDAI before anti-TNF-α treatment (r = 0.42, P < 0.01); B, C: m-OA showed significant correlations with CDAI both before (B) and after (C) the induction of therapy.