Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome

Figure 1 Presentation of the baseline and repeat liver biopsies in 3 metabolic syndrome patients with non-alcoholic steatohepatitis on rosuvastatin (10 mg/d) monotherapy for 12 mo. On the left panel liver biopsies of patients with non-alcoholic steatohepatitis presenting steatosis (fat content of the liver > 30%), hepatocyte ballooning degeneration, diffuse lobular mixed acute and chronic inflammation, and perivenular, perisinusoidal collagen disposition. On the right panel liver biopsies of the same 3 patients after one year monotherapy with 10 mg/d of rosuvastatin presenting total normal liver tissue.

Figure 2 Liver enzyme changes in 20 patients with non-alcoholic steatohepatitis during the 12 mo of rosuvastatin (10 mg/d) monotherapy. The reduction in serum alanine transaminase (ALT), aspartate transaminase (AST) and γ-glutamyl transpeptidase (GGT) levels became statistical significant by the 3^rd month of treatment (ANOVA for the 12 mo period P < 0.001) and for alkaline phosphatase (ALP) by the 6^th mo of treatment (ANOVA for the 12 mo period P = 0.01).