Diagnostic utility of endoscopic ultrasound-guided fine-needle aspiration biopsy for glomus tumor of the stomach

Figure 1 Images of the submucosal mass on the greater curvature of the antrum. A: Plain computed tomography showed a round shaped mass lesion on the gastric antrum (arrow); B: The tumor showed mainly peripheral, not homogeneous, enhancement (arrowhead); C: Esophagogastroduodenoscopy revealed a submucosal tumor on the greater curvature of the antrum with bridging fold; D: Endoscopic ultrasonography showed that the tumor was located on the muscle layer.

Figure 2 Endoscopic ultrasound-guided fine-needle aspiration biopsy pathology. A: Proliferating oval-shaped cells in a small nest formation and a high nuclear cytoplasmic ratio were observed (hematoxylin and eosin stain, × 400 magnification). IHC staining was positive for B: muscle actin, and slightly positive for C: synaptophysin, but negative for D: chromogranin, E: c-kit, F: desmin (× 400).

Figure 3 Gross description. The tumor was mainly homogeneous without necrosis or cystic change and measured 3.5 cm at the largest dimension.

Figure 4 Histology and Immunohistochemical analysis of resected specimen was consistent with the endoscopic ultrasound-guided fine-needle aspiration biopsy pathology results. A: Hematoxylin and eosin stain (× 400); B: Muscle actin; C: Synaptophysin; D: Chromogranin; E: c-kit; F: Desmin (× 400).