Extrahepatic immune related manifestations in chronic hepatitis C virus infection

Figure 1 Immune manifestations of chronic hepatitis C.

Figure 2 Brain magnetic resonance imaging showing foci of demyelination in a hepatitis C virus patient with mixed cryoglobulinemia and pyramidal signs[18].

Figure 3 Membranoproliferative glomerulonephritis in a hepatitis C virus patient: endocapillary proliferation with extensive subendothelial deposits along the glomerular capillary walls. Mesangial deposits are present as well (electron microscopy), adapted from Ko et al[63].

Figure 4 Cryoglobulinemic vasculitis affecting the skin. A: Palpable purpura (personal data); B: Leukocytoclastic vasculitis: predominantly lymphocytic mixed inflammatory infiltrate involving small vessels in the dermis (hematoxylin-eosin, original magnification 200) adapted from Ko et al[63].