Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer

Figure 1 Expression level of miR-193a-5p in colorectal cancer, metastatic lymph node and normal tissues. A: Comparison of miR-193a-5p expression between colorectal cancer and normal mucosa in 69 paired samples. miR-193a-5p expression levels were higher in normal tissues than in cancer tissues (P = 0.0060); B: Comparison of miR-193a-5p expression in primary colorectal cancer (CRC) tissue with and without lymph node metastasis. miR-193a-5p expression levels were significantly lower in primary CRC with lymph node metastasis than without lymph node metastasis (P = 0.0006); C: Correlation of miR-193a-5p expression in primary CRC with lymph node stage (N0/N1/N2). Decreased expression of miR-193a-5p was associated with advanced lymph node stage (P = 0.0007); D: Association of miR-193a-5p expression in colorectal cancer with paired metastatic lymph nodes. No significant difference of miR-193a-5p expression was observed between colorectal cancer and paired metastatic lymph nodes (P = 0.9321). N: Lymph node stage; N0: Stage N0; N1: Stage N1; N2: Stage N2.

Figure 2 Kaplan-Meier survival curves of patients with colorectal cancer based on miR-193a-5p expression. A: Kaplan-Meier disease free survival curves of patients with colorectal cancer (CRC) based on miR-193a-5p expression. Patients in the low expression group had significantly lower disease free survival rates than those in the high expression group (log-rank test, P = 0.0026); B: Kaplan-Meier overall survival curves of patients with CRC based on miR-193a-5p expression. Patients in the low expression group had significantly lower overall survival rates than those in the high expression group (log-rank test, P = 0.0003); C: Kaplan-Meier disease free survival curves of patients with lymph node metastases based on miR-193a-5p expression. Patients in the low expression group had significantly lower disease free survival rates than those in high expression group (log-rank test, P = 0.0262); D: Kaplan-Meier overall survival curves of patients with lymph node metastases based on miR-193a-5p expression. Patients in the low expression group had significantly lower overall survival rates than those in high expression group (log-rank test, P = 0.0230). N: Lymph node stage; N0: Stage N0; N1: Stage N1; N2: Stage N2.