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World J Gastroenterol. Sep 14, 2014; 20(34): 12241-12248
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12241
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12241
Downregulation of miR-193a-5p correlates with lymph node metastasis and poor prognosis in colorectal cancer
Peng Zhang, Deng-Bo Ji, Chang-Zheng Du, Jin Gu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Colorectal Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, China
Hai-Bo Han, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Cell Biology, Peking University Cancer Hospital and Institute, Beijing 100142, China
Yun-Fei Shi, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital and Institute, Beijing 100142, China
Author contributions: Zhang P and Gu J designed the research; Zhang P, Ji DB, Han HB, Shi YF and Du CZ performed the research; Zhang P analyzed the data and wrote the paper; Gu J made critical revisions of the manuscript.
Supported by National Natural Science Foundation of China, No. 30872467, No. 81030040, No. 81201965 and No. 81372593; Beijing Natural Science Foundation, No. 7132052; and the National High Technology Research and Development Program of China (863 Program), No. 2012AA02A506
Correspondence to: Jin Gu, MD, FACS, Professor, Chairman, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Colorectal Surgery, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Haidian District, Beijing 100142, China. zlgujin@126.com
Telephone: +86-10-88141032 Fax: +86-10-88141032
Received: March 14, 2014
Revised: May 8, 2014
Accepted: May 29, 2014
Published online: September 14, 2014
Revised: May 8, 2014
Accepted: May 29, 2014
Published online: September 14, 2014
Core Tip
Core tip: We determined the expression of miR-193a-5p in colorectal cancer (CRC) tissues and metastatic lesions in the lymph nodes using quantitative real-time reverse transcriptase polymerase chain reaction. Downregulation of miR-193a-5p correlated with tumor progression, lymph node metastasis and poor survival in CRC patients. These findings suggest that miR-193a-5p could be used as a molecular biomarker of diagnosis, early-stage metastasis prediction, and prognosis forecast for CRC. This is believed to be the first study to investigate the relationship between miR-193a-5p expression and lymph node metastasis in CRC.