Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. May 28, 2014; 20(20): 6287-6292
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6287
Figure 1
Figure 1 Telomere shortening and liver disease: A possible mechanism. Injuries leading to cell death cause repair and regeneration process which in turn leads to increased cell turnover and therefore to telomere erosion. If a telomerase gene mutation is present, telomerase activity may be reduced and telomere may become critically short leading hepatocyte to senescence. Hepatocyte senescence is a profibrotic state that activates stellate cells responsible for fibrosis[25].