Original Article
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 7, 2014; 20(1): 183-192
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.183
Figure 1
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Figure 1 Representative fluorescent in situ hybridization images of tumors negative for anaplastic lymphoma kinase translocation. The two tumors varied in copy number, but both were negative for anaplastic lymphoma kinase (ALK) translocation, as indicated by the signals that neither had green and orange in close proximity or were fused to form a yellow locus. A: ALK/copy number gain (CNG)-positive cells (≥ 4 copies/cell); B: ALK/CNG-negative cells (< 4 copies/cell); C and D: HE staining of hepatocellular carcinoma cells from A and B (× 200).
Figure 2
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Figure 2 Kaplan-Meier survival curves of hepatocellular carcinoma patients. A: Overall survival of hepatocellular carcinoma (HCC) patients with ≥ 4 anaplastic lymphoma kinase (ALK) gene copies/cell did not differ significantly compared to patients with < 4 ALK gene copies/cell; B: Progression-free survival of HCC patients with ≥ 4 ALK gene copies/cell was significantly different from patients with < 4 ALK gene copies/cell.
Figure 3
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Figure 3 Kaplan-Meier survival curves of hepatocellular carcinoma patients classified according to stage stratum. A and B: In the advanced stage stratum ( IIIand IV), overall survival (OS) (A) and progression-free survival (PFS) (B) of hepatocellular carcinoma (HCC) patients with anaplastic lymphoma kinase copy number gain (ALK/CNG)-positivity and ALK/CNG-negativity; C and D: In the early stage stratum (I and II), OS (C) and PFS (D) of HCC patients with ALK/CNG-positivity and ALK/CNG-negativity.
Figure 4
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Figure 4 Kaplan-Meier survival curves of hepatocellular carcinoma patients classified according to pathological grade. A and B: In grade III disease, overall survival (OS) (A) and progression-free survival (PFS) (B) of hepatocellular carcinoma (HCC) patients with anaplastic lymphoma kinase copy number gain (ALK/CNG)-positivity and ALK/CNG-negativity; C and D: In grade II disease, the OS (C) and PFS (D) of HCC patients with ALK/CNG-positivity and ALK/CNG-negativity.
Figure 5
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Figure 5 Kaplan-Meier survival curves of hepatocellular carcinoma patients classified according to hepatitis B virus status. A and B: In hepatocellular carcinoma (HCC) patients negative for serum hepatitis B virus (HBV) DNA, the overall survival (OS) (A) and progression-free survival (PFS) (B) of HCC patients with anaplastic lymphoma kinase copy number gain (ALK/CNG)-positivity and ALK/CNG-negativity; C and D: The OS (C) and PFS (D) in HCC patients positive for serum HBV DNA.