Regulatory T cells in inflammatory bowel diseases and colorectal cancer

doi:10.3748/wjg.v18.i40.5688

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Oct 28, 2012 (publication date) through Apr 24, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 28, 2012; 18(40): 5688-5694
Published online Oct 28, 2012. doi: 10.3748/wjg.v18.i40.5688

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Figure 1 Phenotypic plasticity of T cells in inflammatory bowel disease. The mucosal concentration of transforming growth factor (TGF)-β influences the interleukin (IL)-23 receptor expression of antigen activated CD4+ T cells, which results imbalance in forkhead box P3 (Foxp3) and retinoic acid-related orphan receptor (RORγt) transcription factor activity. The Foxp3 dependent inhibition or stimulation of RORγt may regulate helper T cell (Th) 17 or Foxp3+ regulatory T cell (T_reg) differentiation. The inflammatory cytokine/chemokine milieu may also influence the phenotypic changes of T cells.

Citation: Műzes G, Molnár B, Sipos F. Regulatory T cells in inflammatory bowel diseases and colorectal cancer. World J Gastroenterol 2012; 18(40): 5688-5694
URL: https://www.wjgnet.com/1007-9327/full/v18/i40/5688.htm
DOI: https://dx.doi.org/10.3748/wjg.v18.i40.5688