Clinical, serological and genetic predictors of inflammatory bowel disease course

Figure 1 Indication for early immunosuppressive therapy. Thiopurines and/or anti-tumor necrosis factor therapy, according to presentation of Crohn’s disease at diagnosis, ¹European Crohn's and Colitis Organisation guidelines and ²Saint-Antoine predictors (2 or 3 of the following items at diagnosis are predictive for subsequent 5-year unfavourable course: Age < 40 years, need for systemic steroids and presence of perianal lesions). IT: Immunosuppressive therapy.