Alanine and aspartate aminotransferase and glutamine-cycling pathway: Their roles in pathogenesis of metabolic syndrome

Figure 1 Schematic presentation of the role of aminotransferases alanine and aspartate in metabolic pathways. Alanine and aspartate pathways and their relationship with fatty acid and amino acid metabolism, glycolysis, citrate and urea cycle. Available at: KEGG Metabolic Pathways. http://www.biologie.uni-hamburg.de/b-online/kegg/kegg/Classes/dblinks_java/map/map00252.html.

Figure 2 Integrated functional association analysis of protein and genetic interactions on alanine and aspartate. Pathways, co-expression, co-localization, and protein domain similarity were analyzed by the bioinformatics resource GenMANIA (genemania.org) for the 5 candidate genes [alanine also known as glutamate pyruvate transaminase (GPT) and GPT2], aspartate [also known as glutamate oxaloacetate transaminase (GOT)1 and GOT2, (Table 1)], isocitrate dehydrogenases 1 (IDH1), IDH2 and HNF4 (gray circles) and the predicted related genes by systems biology (open circles). List of gene symbol and gene function is shown in Table 2. Predicted functional pathways and Q values are shown in Table 3.