p53 gene therapy in combination with transcatheter arterial chemoembolization for HCC: One-year follow-up

Figure 1 Contrast computed tomography showing a nodule (3. 5 cm in diameter) in the right upper liver lobe manifested as homogenous enhancement (A); computed tomography scan (b) demonstrating the course of fine needle biopsy under computed tomography guidance with the diagnosis of hepatocellular carcinoma confirmed (B); computed tomography follow-up (c) revealing lipiodol deposit in the mass and spleen infarction after spleen embolization (C) in a 52-year-old man with multiple hepatic nodules, liver cirrhosis, splenomegaly and elevated alpha-fetoprotein.

Figure 2 Contrast computed tomography scan showing a 15 cm × 11. 5 cm hepatocellular carcinoma in the right liver lobe manifested as a heterogenous lower density, partial enhancement and well-differentiated contour (A) and computed tomography follow-up displaying the significant regression of a 8.5 cm x 6 cm lesion with compact lipiodol deposit in a 72-year-old man after 3 p53 gene injections and 4 courses of transcatheter hepatic arterial chemoembolization.

Figure 3 Survival curves for patients following treatment.