A predictive factor for the response to S-1 plus cisplatin in gastric cancer

doi:10.3748/wjg.v16.i36.4575

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Sep 28, 2010 (publication date) through Apr 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2010; 16(36): 4575-4582
Published online Sep 28, 2010. doi: 10.3748/wjg.v16.i36.4575

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Figure 1 Metabolic pathway of 5-fluorouracil. DPD: Dihydropyrimidine dehydrogenase; TS: Thymidylate synthase; TK: Thymidine kinase; TP: Thymidine phosphorylase; UP: Uridine phosphorylase; OPRT: Orotate phosphoribosyl transferase; UK: Uridine kinase.

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Figure 2 Changes in the protein expression level of thymidylate synthase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase. 1st evaluation: Protein expression and response at the first S-1/CDDP chemotherapy; 2nd evaluation: Protein expression and response at the first progression after response or the latest S-1/CDDP chemotherapy. TS: Thymidylate synthase; DPD: Dihydropyrimidine dehydrogenase; OPRT: Orotate phosphoribosyl transferase.

Citation: Miyazaki I, Kawai T, Harada Y, Moriyasu F. A predictive factor for the response to S-1 plus cisplatin in gastric cancer. World J Gastroenterol 2010; 16(36): 4575-4582
URL: https://www.wjgnet.com/1007-9327/full/v16/i36/4575.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i36.4575