Wilson disease: Histopathological correlations with treatment on follow-up liver biopsies

Figure 1 Evolution of the hepatic copper concentration in patients who presented with progression and without progression of the total histological score. Progressors had a higher hepatic copper concentration at all time points, but the difference between the two groups was not significant.

Figure 2 Biopsy of patients 3 and 9. A: Patient 3, initial biopsy, showing steatosis and focal inflammation (HE stain, 200 ×); B: Patient 3, third biopsy, 6 years after diagnosis, showing only rare steatosis and no inflammation (HE stain, 200 ×); C: Patient 3, initial biopsy, with bridging fibrosis (HE stain, 100 ×); D: Patient 3, second biopsy, without portal fibrosis (HE stain, 100 ×). Patient 3 was treated with zinc; E: Patient 9, initial biopsy, showing focal steatosis (HE stain, 200 ×); F: Patient 9, fourth biopsy, 8 years after diagnosis, showing bridging fibrosis and mild inflammation (Van Gieson stain, 100 ×). Patient 9 was treated with zinc.