Modification of sleep architecture in an animal model of experimental cirrhosis

Figure 1 Percentage of Wakefulness (A), SWS II (B), and REM sleep (C) in weekly 8 h sleep recordings during treatment with CCl₄. Numbers at the top of the bars express the number of subjects. ^aP < 0.05, ^bP < 0.01 vs control. Repeated measurements were analyzed by ANOVA.

Figure 2 Frequency of REM sleep bouts observed in weekly eight-hour sleep recordings during treatment with CCl₄. Numbers at the top of the bars express the number of subjects. ^aP < 0.05, ^bP < 0.01 vs control. Repeated measurements were analyzed by ANOVA.

Figure 3 Effects of repeated administration of CCl₄ on liver morphology in rats after 11 wk of CCl₄ treatment. A: Normal aspect of an untreated liver. In a stain with HE, the typical sinusoidal (S) organization can be observed with lobules (L) surrounding the vessels (V). In a higher magnification, a normal hepatocyte (H) can be distinguished; B: The effects of CCl₄. A fibrotic process (F) is evident, with hepatocytes grouped in nodules (N) containing vacuoles. In a higher magnification, the bold arrow indicates hepatocytes with lipidic vacuoles can be observed as well as cells with pycnotic nucleus (P) or in necrosis (triangle).