Topic Highlight
Copyright ©2009 The WJG Press and Baishideng.
World J Gastroenterol. Sep 7, 2009; 15(33): 4105-4110
Published online Sep 7, 2009. doi: 10.3748/wjg.15.4105
Figure 1
Figure 1 Schematic diagram of the bedside-type artificial endocrine pancreas.
Figure 2
Figure 2 Structure of a glucose sensor of the bedside-type artificial endocrine pancreas. The immobilized glucose oxidase was covered with hydrophilic Cuprophan 100 pmol/L.
Figure 3
Figure 3 Mathematical model for insulin infusion algorithm. The stepwise input of glucose concentration [X (t)] and biphasic response of insulin secretion [I (t)] are depicted. The relationship between input and output is expressed in the transfer function. I (s), X (s) and dX (s) are the Laplace transformed form of I (t), X (t) and dX (t)/dt, respectively. T1 and T2 are the first order delay in response.
Figure 4
Figure 4 Bedside-type artificial endocrine pancreas (STG-22, Nikkiso Co. Ltd. Japan).
Figure 5
Figure 5 Number of cases to whom the bedside-type artificial endocrine pancreas had been applied in Japan. Artificial Organs Registry Report in Japan, 2002.
Figure 6
Figure 6 Newly designed wearable artificial endocrine pancreas. The total system is packed into a small unit (12.6 cm ¡Á 2.9 cm ¡Á 9.6 cm) weighing 250 g (KAP-003, Nikkiso). A glucose sensor is placed in the subcutaneous tissue and measures glucose concentration continuously. The blood glucose concentration (BG, in mg/dL) and the insulin infusion rate (IIR, in mU/min) appear every minute on a large LCD display.