Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus

Figure 1 Moderate predominantly lymphocytic mixed portal infiltration and absence of interlobular bile duct destruction (HE, × 400) (A), intralobular severe canalicular cholestasis (HE, × 400) (B), marked cytoplasmic vacuolization in cholangiolar epithelium (HE, × 400) (C), and absence of bile ducts by cytokeratin 19 immunohistochemical staining (IHC, × 400) (D), observed in our patient.

Figure 2 ALT and ALP (A) and total biluribin (B) levels during and after treatment in our case.