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©2008 The WJG Press and Baishideng. All rights reserved.
World J Gastroenterol. Aug 7, 2008; 14(29): 4697-4700
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4697
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4697
Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus
Gokhan Okan, Dermatology Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey
Serpil Yaylaci, Emergency Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey
Onder Peker, Pathology Department, Acibadem Hospital, Bakirkoy 34140, Turkey
Sabahattin Kaymakoglu, Division of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty, Istanbul 34140, Turkey
Murat Saruc, Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey
Author contributions: Okan G, Saruc M, Yaylaci S, Kayma-koglu S followed up the patient; Peker O performed the pathologic evaluation; Okan G, Saruc M, Yaylaci S wrote the paper; Okan G searched the literature; Okan G, Yaylaci S, Saruc M supported financially.
Correspondence to: Dr. Murat Saruc, Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey. msaruc@acibadem.com.tr
Telephone: +9-212-4144444
Fax: +9-212-4145170
Received: May 4, 2008
Revised: July 7, 2008
Accepted: July 14, 2008
Published online: August 7, 2008
Revised: July 7, 2008
Accepted: July 14, 2008
Published online: August 7, 2008
Abstract
Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient with ciprofloxacin-induced SJS and acute onset of VBDS, and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management.