Role of alcohol in the regulation of iron metabolism

Figure 1 Regulation of iron metabolism by hepcidin. Hepcidin peptide, which is synthesized by the liver and released into the circulation, regulates iron homeostasis by inhibiting duodenal iron transport and the release of iron from macrophages.

Figure 2 A: Modulators of hepcidin synthesis in the liver. Transferrin receptor 2 (TrfR2), Hfe and beta-2 microglobulin (B2M) complex; hemojuvelin (Hjv) and bone morphogenic protein receptor (BMPR) complex. B: Alcohol-mediated regulation of hepcidin transcription in the liver may involve both parenchymal and non-parenchymal cells of the liver.