Crohn’s disease: Innate immunodeficiency?

Figure 1 Impairment of different innate immune mechanisms. These mechanisms play a central role in the homeostasis of intestinal barrier function. Identified environmental risks and genetic susceptibility may contribute to the innate immune dysfunction.

Figure 2 Targets of immunostimulation therapy in Crohn’s disease. Potential therapies encompass interventions focused on augmenting the intestinal innate immune function in different mechanisms of action.