Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

Figure 1 Effects of melatonin (50 mg/kg) treatment on the pancreatic weight/body weight ratio (p. w./b.w.) (A), serum amylase activity (B), amount of malonyl-dialdehyde in the pancreas (C) and liver (D) in L-arginine-induced (2 x 3.2 g/kg) acute pancreatitis. Means ± SE of results on 5 animals in each group are shown. ^aP<0.05 vs group A; ^cP<0.05 vs group C.

Figure 2 Effects of melatonin (50 mg/kg) treatment on the total SOD and Mn-SOD activities of the pancreas (A, C) and liver (B, D) in L-arginine-induced (2 x 3. 2 g/kg) acute pancreatitis. Means ± SE of results on 5 animals in each group are shown. ^aP<0.05 vs group A; ^cP<0.05 vs group C.

Figure 3 Effects of melatonin (50 mg/kg) treatment on the Cu/Zn-SOD and CAT activities of the pancreas (A, C) and liver (B, D) in L-arginine-induced (2 x 3. 2 g/kg) acute pancreatitis. Means ± SE of results on 5 animals in each group are shown. ^aP<0.05 vs group A; ^cP<0.05 vs group C.

Figure 4 Effects of melatonin (50 mg/kg) treatment on the pancreatic GSH content (A), liver GPx activity (B), pancreatic myeloperoxidase activity (C) and pancreatic IL-6 content (D) in L-arginine-induced (2 x 3,2 g/kg) acute pancreatitis. Means ± SE of results on 5 animals in each group are shown. ^aP < 0.05 vs group A; ^cP < 0.05 vs group C.