Rosuvastatin reduces rat intestinal ischemia-reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein

Figure 1 Dose-response of rosuvastatin on acute intestinal I-R injury in rats (mean ±SE). A: Intraluminal protein; B: Hemoglobin. ^bP<0.01 vs Sham, ^aP<0.05, ^dP<0.01 vs Vehicle + I-R.

Figure 2 Histological appearance of the small intestine in rats (HE ×20). N: Sham. C: I-R. R: I-R plus rosuvastatin.

Figure 3 Effects of rosuvastatin on lipid peroxide concentrations and neutrophil accumulation in the intestinal mucosa of rats treated with I-R (mean±SE). A: TBA-reactive substance; B: Myeloperoxidase activity. ^bP<0.01 vs Sham, ^aP<0.05 vs Vehicle + I-R.

Figure 4 Effects of rosuvastatin on the intestinal CINC-1 and TNF-α after I-R in rats (mean+SE). A: CINC-1; B: TNF-α. ^bP<0.01 vs Sham, ^aP<0.05 vs Vehicle + I-R.

Figure 5 Effects of rosuvastatin on the expression of CINC-1 and TNF-α mRNA in the intestinal mucosa after I-R in rats.

Figure 6 Effect of rosuvastatin on eNOS protein expression during I-R. ^aP<0.05 vs Sham, ^cP<0.05 vs Vehicle + I-R.