Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: Roles of nitric oxide and prostaglandin E2

Figure 1 Effect of lipopolysaccharide on the production of NO and PGE₂ in mice blood and intestine. Mice were IP administered with various doses of LPS for 4 h (A, B) or LPS (20 mg/kg) for indicated times (C, D). The blood NO and PGE₂ were determined as described in “Materials and Methods.” Data are expressed as mean±SE of 10 mice. For each column, P<0.05, significantly different from individual control.

Figure 2 Time course of lipopolysaccharide (LPS) on protein expression of iNOS and COX-2 in the small intestine of mice. Mice were administered with LPS (20 mg/kg) for indicated times and the total cell lysates were used to perform the Western blot as described in the “Materials and Methods.”