Apoptosis induction with polo-like kinase-1 antisense phosph-orothioate oligodeoxynucleotide of colon cancer cell line SW480

Figure 1 Inhibition of PLK1 mRNA and protein expression by ASODN demonstrated in Northern blot (A) and Western blot (B) analyses. Lane 1: control group; lane 2-5: groups treated by ASODN (50 nmol/L) after 12, 24, 48 and 72 h.

Figure 2 AI induced by ASODN in control group (A) and PLK1 group (B).

Figure 3 Effect of ASODN on cell cycle distribution of cancer cells. A: Control; B: Treatment cells; C: Cells in G₂/M.