Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver

Figure 1 Expression of CD105 and CD34 as shown by the brown staining of the vasculature in tumor and adjacent non-tumorous liver (×100). A-C are serial sections of tumor tissue, where A shows the CD34 expression, B shows the CD105 expression, and C shows the negative control. D and E are serial sections of adjacent non-tumorous liver, where D shows the CD34 expression, and E shows the CD105 expression. Both D and E illustrate typical focal staining of vessels around the portal vein. F shows a case of diffuse CD105 staining in the non-tumorous liver, whereas such pattern of staining was not seen in the non-tumorous liver by CD34 staining.

Figure 2 Graph of scatter plots showing correlation between scores of IMVD-CD105 vs IMVD-CD34.

Figure 3 Disease-free survival analysis shows the differences in disease-free survival in patients with or without diffuse pattern of CD105 staining in non-tumorous livers. Five patients were excluded from the analysis because of hospital mortality or palliative resection with positive resection margins.