Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10

Figure 1 Effect of IL-10 on liver histological change in rats with hepatic fibrosis (HE×100). A: Rat liver in group N; B: Rat liver in group C in the 7^th wk; C: Rat liver in group I in the 7^th wk; D: Rat liver in group C in the 11^th wk; E: Rat liver in group I in the 11^th wk.

Figure 2 Desmin expression of HSC cultured for five days by immunochemistry (SP×100).

Figure 3 Expression of MMP-2 (A, B) and TIMP-1 (C, D) of HSC in group C and group I during the 7^th wk (SP×100).

Figure 4 Agarose gel electrophoresis of RT-PCR product of MMP-2 gene (A) and TIMP-1 gene (B). Lanes 1–3: groups N, C and I in the 7^th wk; lanes 4–6: groups N, C and I in the 11^th wk; M: 100-bp DNA ladder.