Treatment of pig serum-induced rat liver fibrosis with Boschniakia rossica, oxymatrine and interferon-α

Figure 1 Histological findings in model group. Livers stained with Sirius-red (D) and HE (C) showed an extensive accumulation of collogens. The accumulation of collagens was higher in model group than in BR group as shown in Figures 1A,1B,1E,1F,1H,1I and 1J.

Figure 2 Expression of TGF-β1 in liver tissue. A: RT-PCR products of TGF-β1 mRNA in liver tissue resolved on 1.0% agarose gel (M: markers;1: Control; 2: Model; 3: BR; 4: OM; 5: IFN-α); B: Results of model group rat liver specimens stained with IHC. Lots of α-SMA positive cells, hepatic cord lined up in disorder and fibrosis septum could be seen; C-F: Liver cells stained with IHC (×200) in control, BR, OM and IFN-alpha groups respectively.