Effect of Helicobacter pylori VacA on gene expression of gastric cancer cells

Figure 1 Effects of H pylori culture supernatant containing VacA on cytoskeleton of HeLa and SGC7901 cells: HeLa and SGC7901 cells co-cultured with VacA^-BCS for 48 h (panels A and B) and 24 h (panels C and D), showed normal microtubules dispersed in a radial fashion throughout the cytosol, HeLa and SGC7901 cells co-cultured with VacA⁺BCS for 24 h (panels C and D) showed collapse and disruption of the microtubule cytoarchitecture. HeLa and SGC790 cells co-cultured with VacA⁺BCS for 48 h (panels E and F), showed a lower density of microtubular fibers and even partially disappeared.