Pathogenicty and immune prophylaxis of cag pathogenicity island gene knockout homogenic mutants

Figure 1 Eqivalent growth of wildtype and knockout strains after 2 d culture.

Figure 2 Binding of cag PAI wildtype H pylori and their mutant to gastric epithelial cell Kato-III.

Figure 3 Apotosis of gastric epithelial cells induced by positive cagPAI and knockout H pylori strains (determined by ELISA ^aP < 0. 05 vs the control).

Figure 4 Semi-quantatative results of bacteria by histological examination. ^aP < 0.05 vs PBS control.

Figure 5 Specific proliferation index of immunized mice (compared to PBS group).