Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma: Correlation with microvessel density

Figure 1 Immunohistochemical demonstration of iNOS expression in cases of pancreatic adenocarcinomas with moderate (A) and strong (B) staining intensity. There was a cytoplasmatic staining pattern with distribution within the tumor. No nuclear staining was observed. Cells of the islets of Langerhans were also positive (C). Original magnification × 200, Hematoxylin counterstaining.

Figure 2 COX-2 immunohistochemistry in pancreatic adenocarcinomas shown in a case with (A) moderate and (B) strong staining intensity. Immunostaining was restricted to the cytoplasm. Even in the case with high staining only a portion of tumor cells expressed COX-2. Cells of the islets of Langerhans were also stained (C). Original magnification × 200, Hematoxylin counterstaining.

Figure 3 Comparison of iNOS or COX-2 expression with microvessel density. No statistically significant correlation could be noted.