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World J Gastroenterol. Jan 14, 2027; 33(2): 125855
Published online Jan 14, 2027. doi: 10.3748/wjg.125855
Published online Jan 14, 2027. doi: 10.3748/wjg.125855
Letter to the Editor: Tumor necrosis factor-α-mediated β-cell death in acute pancreatitis-addressing etiology, cytokine crosstalk, and pyroptosis
Hai-Feng Chen, Department of Gastroenterology, Taicang Affiliated Hospital of Soochow University (The First People’s Hospital of Taicang), Taicang 215400, Jiangsu Province, China
Ting-Ting Wang, Department of Nephrology, Taicang Affiliated Hospital of Soochow Uni
Wei-Ping Li, Department of Gastrointestinal Surgery, Taicang Affiliated Hospital of Soochow University (The First People’s Hospital of Taicang), Suzhou 215400, Jiangsu Province, China
Author contributions: Chen HF and Li WP drafted this letter; Wang TT and Li WP critically revised it; all authors read and approved the final version.
AI contribution statement: As non-native English speakers, we used Youdao Translate for the initial Chinese-to-English translation, and subsequently had the manuscript professionally edited by CureEdit for readability and grammar.
Supported by Taicang Science and Technology Program, No. TC2021JCYL21; and the Taicang Municipal Health Talent Research Project, No. TCWS202514.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Wei-Ping Li, Department of Gastrointestinal Surgery, Taicang Affiliated Hospital of Soochow University (The First People’s Hospital of Taicang), No. 58 South Changsheng Road, Suzhou 215400, Jiangsu Province, China. question12397@163.com
Received: July 30, 2026
Revised: September 12, 2026
Accepted: October 23, 2026
Published online: January 14, 2027
Processing time: 105 Days and 1.3 Hours
Revised: September 12, 2026
Accepted: October 23, 2026
Published online: January 14, 2027
Processing time: 105 Days and 1.3 Hours
Core Tip
Core Tip: This letter discusses three issues arising from the model proposed by Lizzi and Massimi: Etiology-specific differences in acute pancreatitis, cytokine crosstalk, and the potential involvement of pyroptotic pathways in β-cell injury.