Robot-assisted massage is associated with improved duodenal barrier-related outcomes in a rabbit model of functional dyspepsia
Yi-Chao Zhang, Wu-Xia Yang, Jia-Lu Hou, Zi-Xuan Wang, Zhi-Kai Huang, Hong-Lin Li, Ming-Zheng Kek, De-Rong Lin, Ru-Hao Wu, Ji-Hong Wang
Yi-Chao Zhang, Jia-Lu Hou, Zhi-Kai Huang, Hong-Lin Li, Ming-Zheng Kek, Ji-Hong Wang, Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong Province, China
Wu-Xia Yang, Tianjin Medical University, Tianjin 300070, China
Zi-Xuan Wang, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao Special Administrative Region 999078, China
De-Rong Lin, Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan 523000, Guangdong Province, China
Ru-Hao Wu, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China
Co-first authors: Yi-Chao Zhang and Wu-Xia Yang.
Author contributions: Zhang YC and Yang WX contributed equally to this article, they are the co-first authors of this manuscript; Zhang YC contributed to the study design, experimental implementation, data analysis, and manuscript drafting; Yang WX contributed to methodology optimization, data interpretation, and manuscript revision; Hou JL, Wang ZX, Huang ZK, Li HL, Kek MZ, Lin DR, and Wu RH participated in animal experiments, sample collection, molecular assays, and data curation; Wang JH supervised the study, provided conceptual guidance, secured resources, and critically revised the manuscript; and all authors reviewed and approved the final manuscript.
AI contribution statement: During the preparation of this manuscript, the authors used OpenAI Codex, powered by GPT-5 (OpenAI,
https://openai.com), solely for English-language editing, formatting, and submission-preparation assistance. The authors reviewed and edited all output and take full responsibility for the content. No generative artificial intelligence was used to generate study data, perform statistical analyses, create figures, or draw scientific conclusions.
Supported by the National Natural Science Foundation of China, No. 82474667.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Guangzhou University of Chinese Medicine, approval No. 20241118009.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data that support the findings of this study are available from the corresponding author at
13622882891@163.com upon reasonable request.
Corresponding author: Ji-Hong Wang, PhD, Full Professor, Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, No. 232 Waihuan East Road, Panyu District, Guangzhou 510006, Guangdong Province, China.
13622882891@163.com
Received: July 17, 2026
Revised: August 17, 2026
Accepted: October 10, 2026
Published online: January 14, 2027
Processing time: 112 Days and 15.9 Hours
