Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 28, 2026; 32(48): 121672
Published online Dec 28, 2026. doi: 10.3748/wjg.121672
Published online Dec 28, 2026. doi: 10.3748/wjg.121672
Prognostic value of postoperative CEA/CA19-9 positivity and elevation relative to preoperative levels in gastric cancer
Li-Xiang Zhang, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
Ning Chang, Yong-Hui Zhang, Xiao-Dong Zhu, En-Ze Zhou, Min-Zhi Sun, Pan-Quan Luo, Zhi-Jian Wei, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
Ye-Zhou Su, Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, Anhui Province, China
Hai Zhu, Department of General Surgery, Anhui Provincial Hospital, Hefei 230036, Anhui Province, China
A-Man Xu, Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Qing Liu, Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Co-first authors: Li-Xiang Zhang and Ning Chang.
Co-corresponding authors: Qing Liu and Zhi-Jian Wei.
Author contributions: Zhang LX and Chang N contributed equally as co-first authors; Zhang LX, Su YZ, and Chang N collected the clinical information of patients, performed the statistical analysis, and completed the writing of the manuscript; Zhang YH, Zhu H, and Zhu XD participated in collecting the clinical information of patients and revising the statistical methods of the investigation; Liu Q, Sun MZ, Zhou EZ, Xu AM, and Luo PQ designed the main study and critically revised the manuscript; Wei ZJ provided follow-up information and financial support; Liu Q and Wei ZJ contributed equally as co-corresponding authors. All authors read and approved the final manuscript.
AI contribution statement: The authors declare that no AI tools were used in this manuscript.
Institutional review board statement: This study was approved by Institutional Review Board of the First Affiliated Hospital of Anhui Medical University, No. PJ2025-01-62.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that was obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request.
Corresponding author: Zhi-Jian Wei, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230031, Anhui Province, China. yfy1041018@fy.ahmu.edu.cn
Received: April 7, 2026
Revised: July 2, 2026
Accepted: July 27, 2026
Published online: December 28, 2026
Processing time: 212 Days and 20.1 Hours
Revised: July 2, 2026
Accepted: July 27, 2026
Published online: December 28, 2026
Processing time: 212 Days and 20.1 Hours
Core Tip
Core Tip: Carcinoembryonic antigen and carbohydrate antigen 19-9 are representative tumor markers of gastric cancer and are considered useful for detecting recurrence after curative gastrectomy. Postoperative elevation of tumor markers was more informative of prognosis of gastric cancer compared to preoperative tumor marker levels. Postoperative elevation of carcinoembryonic antigen and carbohydrate antigen 19-9 was an independent prognostic risk factor for overall and disease-free survival.