Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Dec 7, 2026; 32(45): 122498
Published online Dec 7, 2026. doi: 10.3748/wjg.122498
Published online Dec 7, 2026. doi: 10.3748/wjg.122498
Dendrobium officinale polysaccharides attenuates spasmolytic polypeptide-expressing metaplasia via dual modulation of gastric epithelial cell fate and macrophage polarization
Yi Zhao, Xue-Feng Lu, Lu Liu, Hong Fang, Shuo Sun, Hong-Ning Liu, Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China
You-Zhi Sun, School of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, Jiangxi Province, China
Co-corresponding authors: Hong-Ning Liu and You-Zhi Sun.
Author contributions: Zhao Y designed the study, created the figures, and drafted the manuscript; Lu XF conducted the experiments, performed data analysis and statistics, created the figures, and also contributed to drafting the manuscript; Liu L and Fang H carried out the experiments and reviewed the data analysis and statistics; Sun S conducted the experiments and verified the data analysis and statistics; Liu HN and Sun YZ designed the study and revised the manuscript for important intellectual content as co-corresponding authors; all of the authors read and approved the final version of the manuscript to be published.
AI contribution statement: Polish the language using Wordvice AI to ensure professionalism and native-like expression.
Supported by National Natural Science Foundation of China, No. 82560860; Jiangxi Provincial Natural Science Foundation Project, No. 20242BAB25562 and No. 20262BAC250038; and National Key R&D Program of China, No. 2024YFE0104600.
Institutional animal care and use committee statement: All animal studies were granted by the Ethics Committee of the Animal Center of Jiangxi University of Chinese Medicine (No. JZLLSC20220606 and date of approval 5/29/2024).
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data supporting this article have been included within the manuscript. All relevant data are available upon request from the corresponding author.
Corresponding author: You-Zhi Sun, Professor, School of Chinese Medicine, Jiangxi University of Chinese Medicine, No. 1688 Meiling Avenue, Xinjian District, Nanchang 330004, Jiangxi Province, China. 20040792@jxutcm.edu.cn
Received: April 21, 2026
Revised: June 14, 2026
Accepted: July 3, 2026
Published online: December 7, 2026
Processing time: 177 Days and 18.2 Hours
Revised: June 14, 2026
Accepted: July 3, 2026
Published online: December 7, 2026
Processing time: 177 Days and 18.2 Hours
Core Tip
Core Tip: Dendrobium officinale polysaccharides upregulated the expression of ATP4a and GS II, while concurrently reducing the differentiation of chief cells. Furthermore, it inhibited M2 macrophage polarization via the IL-13/STAT6 signaling pathway and was identified as a protective agent against spasmolytic polypeptide-expressing metaplasia.