Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 28, 2026; 32(44): 121972
Published online Nov 28, 2026. doi: 10.3748/wjg.121972
Published online Nov 28, 2026. doi: 10.3748/wjg.121972
Applications of nanozymes in the diagnosis and treatment of gastrointestinal malignancies
Yue-Cui Tang, Ru-Ping Gao, Yu-Xi Lv, Department of Surgery, Shandong University of Tradi
Yu Wang, Xiao-Bo Guo, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250101, Shandong Province, China
Author contributions: Tang YC and Guo XB wrote the paper; Gao RP, Lv YX, and Wang Y searched for articles and reviewed manuscripts; and all authors have read and approved the final manuscript.
AI contribution statement: AI tools (GPT and Gemini) were used solely for linguistic refinement and formatting assistance. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Xiao-Bo Guo, MD, Professor, Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 9677 Jingshi Road, Jinan 250101, Shandong Province, China. guo992352@hotmail.com
Received: April 7, 2026
Revised: June 12, 2026
Accepted: July 20, 2026
Published online: November 28, 2026
Processing time: 176 Days and 9.5 Hours
Revised: June 12, 2026
Accepted: July 20, 2026
Published online: November 28, 2026
Processing time: 176 Days and 9.5 Hours
Core Tip
Core Tip: Nanozymes, with their enzyme-mimicking catalytic activity, have demonstrated high sensitivity and stability in tumor marker detection, molecular imaging diagnosis, and pathological staining. Additionally, they achieve synergistic therapy for gastrointestinal (GI) malignancies through the generation of reactive oxygen species, regulation of the immune microenvironment, and as multifunctional drug carriers. Despite challenges remaining in biosafety, targeting, and clinical translation, they offer a new strategy for the early diagnosis and precise treatment of GI malignancies.