Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2026; 32(43): 121090
Published online Nov 21, 2026. doi: 10.3748/wjg.121090
Published online Nov 21, 2026. doi: 10.3748/wjg.121090
Complete clip closure with staged triple-lumen feeding tube reduces delayed adverse events after duodenal endoscopic submucosal dissection
Yue Song, Jing Wang, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing 100142, China
Fan Meng, Department of Occupational Health and Environmental Health, School of Public Health, Hebei Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
Qi Wu, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Endoscopy Center, Peking University Cancer Hospital and Institute, Beijing 100142, China
Co-first authors: Yue Song and Jing Wang.
Author contributions: Song Y and Wang J contributed equally to this manuscript and are co-first authors; Song Y designed the study, collected and analyzed data, and wrote the manuscript; Wang J was responsible for the methodology and project administration; Meng F performed the statistical analysis; Wu Q was responsible for the conceptualization and design of the study and acquisition of funding; and all authors read and approved the final version.
Supported by the Beijing Research Ward Excellence Program, No. BRWEP2024W032150100 and No. BRWEP2024W032150112; Hygiene and Health Development Scientific Research Fostering Plan of Haidian District, Beijing, No. HP2024-19-503002; Beijing Municipal Administration of Hospitals Incubating Program, No. PX2024041; and Application Demonstration and Promotion of Ultrasound/Confocal Endoscopy Technology in the Diagnosis and Treatment of Esophageal Tumors, No. 2023YFC2413802.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Peking University Cancer Hospital (approval No. 2017KT103).
Informed consent statement: All study participants, or their legal guardians, had provided informed written consent at the time of data collection.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: The datasets used and/or analyzed during the current study are not publicly available due to patient privacy and ethical restrictions but are available from the corresponding author on reasonable request. The original contributions presented in the study are included in the article and the Supplementary material.
Corresponding author: Qi Wu, MD, Professor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Endoscopy Center, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuqi1973@bjmu.edu.cn
Received: March 17, 2026
Revised: April 10, 2026
Accepted: April 22, 2026
Published online: November 21, 2026
Processing time: 195 Days and 10.3 Hours
Revised: April 10, 2026
Accepted: April 22, 2026
Published online: November 21, 2026
Processing time: 195 Days and 10.3 Hours
Core Tip
Core Tip: Delayed adverse events (AEs) remain a major challenge after duodenal endoscopic submucosal dissection (ESD). In this real-world cohort, complete clip closure and postoperative triple-lumen feeding tube management were independently associated with fewer delayed AEs, with patients receiving both measures exhibiting the lowest observed complication rate. Furthermore, triple-lumen feeding tube drainage was associated with attenuated early postoperative inflammation and improved nutritional status. These results provide practical evidence to inform perioperative management in high-risk duodenal ESD.