Human umbilical cord mesenchymal stem cell-derived exosomes alleviate experimental colitis by maintaining the intestinal barrier and remodeling macrophage polarization
Lian-Lian Tian, Jun Zhu, Zhen-Zhen Fan, Yan-Ting Shi, Liu-Qing Zhao, Jin-Dan He, Jie Liang
Lian-Lian Tian, Zhen-Zhen Fan, Yan-Ting Shi, Liu-Qing Zhao, Jin-Dan He, Jie Liang, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Jun Zhu, Department of General Surgery, The Southern Theater Air Force Hospital, Guangzhou 510000, Guangdong Province, China
Co-first authors: Lian-Lian Tian and Jun Zhu.
Author contributions: Tian LL and Zhu J designed and performed the experiments and analyzed the experimental data, and they contributed equally to this work as co-first authors; Tian LL drafted the original manuscript; Fan ZZ revised the figures; Shi YT, Zhao LQ, and He JD revised the manuscript; Liang J supervised the work and edited the manuscript; all authors have read and approved the final manuscript.
AI contribution statement: During the preparation of this work, we did not use any AI tools.
Supported by the National Natural Science Foundation of China, No. 82370588, No. 82570614, and No. 92259302; The Innovative Medical Research Boosting Project, No. XJZT25CX41; and Special Project for Clinical New Technologies of Xijing Hospital, No. 2024XJSY17.
Institutional review board statement: This study did not involve human participants; therefore, institutional review board approval was not required..
Institutional animal care and use committee statement: All animal experiments were conducted in compliance with the guidelines of the National Institutes of Health (NIH) and were approved by the Ethics Committee for Animal Experiments of Fourth Military Medical University (approval No. IACUC-20240522).
Conflict-of-interest statement: The authors declare that they have no conflict of interest to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data generated in this study are available upon request from the corresponding author.
Corresponding author: Jie Liang, MD, Professor, State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, No. 127 Changle West Road, Xincheng District, Xi’an 710032, Shaanxi Province, China.
liangjie@fmmu.edu.cn
Received: December 22, 2025
Revised: March 5, 2026
Accepted: September 4, 2026
Published online: November 14, 2026
Processing time: 277 Days and 21.6 Hours
