Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 28, 2026; 32(40): 123728
Published online Oct 28, 2026. doi: 10.3748/wjg.123728
Published online Oct 28, 2026. doi: 10.3748/wjg.123728
Letter to the Editor: Optimizing Helicobacter pylori eradication and cardiovascular risk assessment in long-term aspirin users: Methodological perspective
Xin Yu, Xing-Yong Huang, Xiao-Yue Zhang, Yi-Jia Sun, Kai Zhang, Department of Gastro
Peng Lu, School of Life Sciences, Ludong University, Yantai 264025, Shandong Province, China
Shou-Liang Cai, Department of Thyroid and Breast Surgery, Ansteel General Hospital, Anshan 114002, Liaoning Province, China
Co-first authors: Xin Yu and Xing-Yong Huang.
Author contributions: Zhang K designed the overall concept, outlined the manuscript, and critically revised the manuscript for important intellectual content; Yu X and Huang XY drafted the manuscript and performed the comprehensive literature review as co-first authors; Zhang XY contributed to the clinical perspectives on cardiovascular outcomes and pathophysiological mechanisms; Sun YJ and Lu P provided critical insights into advanced endoscopic surveillance strategies; Cai SL contributed to the methodological assessment and data interpretation. All authors reviewed and approved the final version of the manuscript.
AI contribution statement: The authors assume full responsibility and accountability for the entirety of this manuscript, including portions where Doubao was used as a supporting technology for language refinement and text smoothing. All AI-assisted outputs were rigorously scrutinized, validated, and verified by the authors under strict human oversight. AI tools were not used to generate original scientific data, perform independent analyses, or draw scientific conclusions.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Kai Zhang, MD, PhD, Associate Professor, Department of Gastroen
Received: May 28, 2026
Revised: July 13, 2026
Accepted: July 28, 2026
Published online: October 28, 2026
Processing time: 107 Days and 18.9 Hours
Revised: July 13, 2026
Accepted: July 28, 2026
Published online: October 28, 2026
Processing time: 107 Days and 18.9 Hours
Core Tip
Core Tip: Semeya et al provided exceptional real-world evidence of the benefits of Helicobacter pylori eradication for chronic aspirin users. To further upgrade this multidisciplinary clinical model, we discuss the safety boundaries of intensified alternative therapies in elderly patients and the specific pathophysiological cascades driving vascular stability. Rather than universal screening, we propose a highly targeted, risk-stratified surveillance approach utilizing advanced imaging to safely balance clinical justification with cost-effectiveness thresholds.