Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 28, 2026; 32(40): 117677
Published online Oct 28, 2026. doi: 10.3748/wjg.117677
Published online Oct 28, 2026. doi: 10.3748/wjg.117677
ARPC1B contributes to colorectal cancer progression and is associated with programmed death-ligand 1 expression
Yi-Lin Chen, Bei-An Lin, Xin Chen, Xiao-Ping Liu, Jing-Shan Huang, Department of General Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Author contributions: Chen YL and Huang JS conceived and designed the study; Chen YL and Lin BA performed the experiments; Chen X and Liu XP processed and analyzed the data; Huang JS wrote the manuscript; All the authors approved the manuscript.
AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.
Supported by the Natural Science Foundation of Fujian Province, No. 2022J01773.
Institutional review board statement: This study was approved by the Ethic Committee of the Second Affiliated Hospital of Fujian Medical University, No. 2022-552.
Institutional animal care and use committee statement: The animal experiments conducted in this study were overseen by Medical Ethics Committee of the Second Affiliated Hospital of Fujian Medical University, No. 2022-552.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Jing-Shan Huang, MD, Doctor, Department of General Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Quanzhou 362000, Fujian Province, China. hjs_mountain99@sina.com
Received: March 25, 2026
Revised: May 8, 2026
Accepted: June 5, 2026
Published online: October 28, 2026
Processing time: 170 Days and 18.9 Hours
Revised: May 8, 2026
Accepted: June 5, 2026
Published online: October 28, 2026
Processing time: 170 Days and 18.9 Hours
Core Tip
Core Tip: ARPC1B promotes colorectal cancer proliferation and metastasis and is associated with programmed death-ligand 1 (PD-L1) expression. Suppressed tumor growth and pulmonary metastasis are observed after knocking down ARPC1B expression. This study functionally links ARPC1B to PD-L1-associated aggressive biological behaviors.