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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 21, 2026; 32(39): 120167
Published online Oct 21, 2026. doi: 10.3748/wjg.120167
Postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: A prospective cohort study
Guan-Yu Yang, Xiao-Fei Zhang, Xin Zhao, Huan Qu, Piao Zhou, Yan Wang, Shu-Min Tu, Zheng-Yuan Xia, Qin-Jun Chu
Guan-Yu Yang, Xiao-Fei Zhang, Xin Zhao, Huan Qu, Piao Zhou, Yan Wang, Shu-Min Tu, Zheng-Yuan Xia, Qin-Jun Chu, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China
Co-first authors: Guan-Yu Yang and Xiao-Fei Zhang.
Author contributions: Yang GY and Zhang XF wrote the original draft as co-first authors; Yang GY, Zhang XF, Zhao X, Qu H, Zhou P, Wang Y, Tu SM, and Xia ZY participated in the formal analysis and investigation; Yang GY, Zhang XF, and Chu QJ designed the study; Zhang XF and Chu QJ developed the methodology; Yang GY, Zhang XF, Zhao X, Qu H, Zhou P, Wang Y, Tu SM, Xia ZY, and Chu QJ participated in the review and editing; all of the authors read and approved the final version of the manuscript to be published.
AI contribution statement: The authors used DeepSeek. This tool was employed for language polishing – to improve clarity, grammar, and phrasing – in both the response-to-reviewers letter and the main manuscript. No part of the main manuscript text – abstract, introduction, materials and methods, results, discussion, or conclusion – was generated by AI.
Institutional review board statement: This single-center prospective cohort study was approved by the Medical Ethics Committee of Zhengzhou Central Hospital Affiliated to Zhengzhou University (approval No. 202207) on January 10, 2022.
Clinical trial registration statement: Not applicable.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
Corresponding author: Qin-Jun Chu, MD, PhD, Professor, Department of Anesthesiology and Perioperative Medicine, Zhengzhou Central Hospital Affiliated to Zhengzhou University, No. 16 Tongbai North Road, Zhongyuan District, Zhengzhou 450007, Henan Province, China. jimmynetchu@163.com
Received: February 24, 2026
Revised: March 30, 2026
Accepted: May 25, 2026
Published online: October 21, 2026
Processing time: 201 Days and 19.5 Hours
Core Tip

Core Tip: In this prospective cohort study of 1054 patients undergoing laparoscopic sleeve gastrectomy, postoperative nausea and vomiting (PONV) remained highly prevalent despite multimodal prophylaxis, affecting 76.3% of patients. Using the validated Index of Nausea, Vomiting, and Retching, we found that intraoperative dexmedetomidine was associated with lower odds of PONV, whereas Apfel scores of 3-4 were associated with a substantially increased risk even with guideline-based prevention. These findings suggest a potential benefit of dexmedetomidine in this setting, although randomized controlled trials are needed to confirm causality. More effective antiemetic strategies, including additional pharmacological and non-pharmacological approaches, may be warranted for patients at high risk of PONV after laparoscopic sleeve gastrectomy.

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