Letter to the Editor: Skeletal muscle transcriptomics in metabolic dysfunction-associated steatotic liver disease - balancing promise with validation

doi:10.3748/wjg.121683

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 14, 2026; 32(38): 121683
Published online Oct 14, 2026. doi: 10.3748/wjg.121683

Letter to the Editor: Skeletal muscle transcriptomics in metabolic dysfunction-associated steatotic liver disease - balancing promise with validation

María Victoria Delpino

María Victoria Delpino, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Buenos Aires C1121ABG, Argentina

Author contributions: The author solely conceived, drafted, critically revised, and approved the final version of the manuscript.

AI contribution statement: ChatGPT was used in preparing the manuscript and reviewer response documents. ChatGPT was used solely for language polishing and grammar correction. It was not used for translation, data analysis, interpretation of results, scientific writing, or content generation.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: María Victoria Delpino, PhD, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Paraguay 2155, Buenos Aires C1121ABG, Argentina. mdelpino@ffyb.uba.ar

Received: March 30, 2026
Revised: April 16, 2026
Accepted: May 18, 2026
Published online: October 14, 2026
Processing time: 158 Days and 24 Hours

Core Tip

Core Tip: Zhang et al identify exercise-responsive skeletal muscle genes that may help explain the metabolic benefits of exercise in metabolic dysfunction-associated steatotic liver disease. Their integrative approach is promising, but these candidate markers require validation in well-designed, multi-center prospective human cohorts with paired liver histology or imaging data, additional human validation and functional studies before they can be considered for clinical use.