Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 7, 2026; 32(37): 120860
Published online Oct 7, 2026. doi: 10.3748/wjg.120860
Published online Oct 7, 2026. doi: 10.3748/wjg.120860
Transjugular intrahepatic portosystemic shunt combined with viral suppression reverses decompensated cirrhosis: Two case reports
Jun Tie, Xu-Long Yuan, Jing Niu, Jiao Xu, Yong-Quan Shi, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi’an 710032, Shaanxi Province, China
Author contributions: Tie J and Yuan XL performed the transjugular intrahepatic portosystemic shunt procedure; Tie J, Yuan XL, and Shi YQ were involved in patient management; Tie J drafted the manuscript and serves as the study guarantor; Niu J and Xu J collected the clinical data; All authors thoroughly reviewed and approved the final manuscript.
Informed consent statement: Written informed consent was obtained from the participants for publication of the case details and accompanying images.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jun Tie, MD, PhD, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Air Force Medical University, No. 127 Changle West Road, Xi’an 710032, Shaanxi Province, China. tiejun7776@163.com
Received: March 11, 2026
Revised: April 1, 2026
Accepted: May 6, 2026
Published online: October 7, 2026
Processing time: 174 Days and 18.9 Hours
Revised: April 1, 2026
Accepted: May 6, 2026
Published online: October 7, 2026
Processing time: 174 Days and 18.9 Hours
Core Tip
Core Tip: This case series demonstrates that decompensated cirrhosis—long thought to irreversible—can be clinically and histologically reversed. The key is combining transjugular intrahepatic portosystemic shunt to alleviate portal hypertension with sustained antiviral therapy to control the underlying etiology.