Letter to the Editor: Adjunctive low-dose flupentixol-melitracen with lansoprazole rapidly improves functional dyspepsia - implications from a randomized, double-blind trial

doi:10.3748/wjg.120735

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastroenterol. Oct 7, 2026; 32(37): 120735
Published online Oct 7, 2026. doi: 10.3748/wjg.120735

Letter to the Editor: Adjunctive low-dose flupentixol-melitracen with lansoprazole rapidly improves functional dyspepsia - implications from a randomized, double-blind trial

Snehasis Nayak

Snehasis Nayak, Department of Student Research Committee, University of Visayas Gullas College of Medicine, Cebu 6000, Philippines

Author contributions: Nayak S was responsible for original draft, data curation, investigation, writing of the manuscript.

AI contribution statement: AI-based tools like ChatGPT and Grammarly were used only for language refinement, grammar correction, and improving clarity. The author developed all scientific content, interpretation, and writing. AI tools were not used for data generation, analysis, study design, or interpreting results. As the sole author, I take full responsibility for the accuracy, integrity, and originality of the manuscript, as well as for any errors or inaccuracies that may be found.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Corresponding author: Snehasis Nayak, Department of Student Research Committee, University of Visayas Gullas College of Medicine, Banilad, Cebu 6000, Philippines. snehasisnayak37@gmail.com

Received: March 9, 2026
Revised: May 15, 2026
Accepted: June 24, 2026
Published online: October 7, 2026
Processing time: 179 Days and 0.2 Hours

Core Tip

Core Tip: Combining lansoprazole (30 mg daily) with low-dose flupentixol-melitracen can effectively address both the symptoms and psychosocial factors of functional dyspepsia. This commentary discusses the potential role of early gut-brain axis modulation, examines the strengths and limitations of current evidence, highlights regulatory and geographic differences in the use of flupentixol-melitracen, and emphasizes the need for large multicenter studies to identify patients most likely to benefit from this therapeutic approach.