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World J Gastroenterol. Oct 7, 2026; 32(37): 119736
Published online Oct 7, 2026. doi: 10.3748/wjg.119736
Published online Oct 7, 2026. doi: 10.3748/wjg.119736
Predictive model to identify patients requiring extended interferon therapy in chronic hepatitis B
Cheng-Yuan Tsai, Ching-Shan Huang, Department of Clinical Pathology, Cathay General Hospital, Taipei 10630, Taiwan
Author contributions: Tsai CY contributed to data collection and formal analysis; Huang CS contributed to the study conception and design, read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ching-Shan Huang, Professor, Department of Clinical Pathology, Cathay General Hospital, No. 280, Sec 4, Ren Ai Road, Taipei 10630, Taiwan.
Received: February 4, 2026
Revised: April 18, 2026
Accepted: June 12, 2026
Published online: October 7, 2026
Processing time: 208 Days and 16.5 Hours
Revised: April 18, 2026
Accepted: June 12, 2026
Published online: October 7, 2026
Processing time: 208 Days and 16.5 Hours
Core Tip
Core Tip: Yan et al published a study in the World Journal of Gastroenterology regarding interferon therapy for chronic hepatitis B clearance that warrants broad attention. In this editorial, we review their work and contextualize their findings within the scope of similar English-language publications in PubMed. A novel finding of their study is that stable discriminatory ability was noted for both the training cohort (area under the receiver operating characteristic curve = 0.83) and the validation cohort (area under the receiver operating characteristic curve = 0.81), with predictive efficacy unaffected by subgroup characteristics. We also discuss the limitations of their study and address its potential clinical implications.