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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2025; 31(33): 109938
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.109938
Published online Sep 7, 2025. doi: 10.3748/wjg.v31.i33.109938
Risk factors and long-term prognosis for colorectal strictures in ulcerative colitis
Yu-Pei Shao, Tao-Tao Han, Hong Lv, Sun-Ting Yang, Ji Li, Jing-Nan Li, Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China
Qing-Li Zhu, Department of Ultrasound, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China
Author contributions: Shao YP and Li JN designed the study; Shao YP, Han TT, and Lv H acquired and analyzed the data; Shao YP and Yang ST helped with patient follow-up; Lv H, Zhu QL and Li J developed methodology; Li JN provided resources and acquired funding; Shao YP wrote the original draft; Shao YP, Han TT, Lv H, Yang ST, Zhu QL, Li Ji and Li JN participated in review and editing; all authors have read and approved the final version to be published.
Supported by the National Natural Science Foundation of China, No. 82270567; and the Central High-Level Hospital Clinical Research Project of Peking Union Medical College Hospital, No. 2022-PUMCH-B-022 and No. 2022-PUMCH-C-055.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Peking Union Medical College Hospital (No. K24C3372).
Informed consent statement: Signed informed consent was obtained from all participants.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Nan Li, PhD, Professor, Department of Gastroenterology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China. jnli2020@126.com
Received: May 26, 2025
Revised: July 8, 2025
Accepted: August 5, 2025
Published online: September 7, 2025
Processing time: 98 Days and 16.3 Hours
Revised: July 8, 2025
Accepted: August 5, 2025
Published online: September 7, 2025
Processing time: 98 Days and 16.3 Hours
Core Tip
Core Tip: Limited studies have focused on the long-term clinical outcomes and risk factors associated with strictures in ulcerative colitis (UC). This cohort study analyzed 938 UC patients with a median follow-up time of 8.70 years. The incidence of UC strictures was 12.4%, with 8.6% confirmed as malignant. UC patients with strictures had poor treatment efficacy and higher risks of surgery, intestinal complications and colorectal cancer. Age ≥ 40 years at diagnosis and extraintestinal manifestations were risk factors for stricture formation, while vedolizumab use was protective. Sensitivity analysis, excluding malignant strictures, showed consistent findings.