Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2025; 31(28): 108271
Published online Jul 28, 2025. doi: 10.3748/wjg.v31.i28.108271
Phospholipase D2: A biomarker implicated in various pancreatic diseases beyond acute pancreatitis
Ana I Tornel Avelar, Christian Navarro Gerrard, Bryan Adrian Priego Parra
Ana I Tornel Avelar, Department of Gastroenterology, Hospital Civil de Guadalajara “Fray Antonio Alcalde”, Guadalajara 44280, Jalisco, Mexico
Christian Navarro Gerrard, Department of Endoscopy, Hospital Star Médica Chihuahua, Chihuahua 31110, Chihuahua, Mexico
Christian Navarro Gerrard, Department of Gastroenterology, Hospital Ángeles Chihuahua, Chihuahua 31217, Chihuahua, Mexico
Bryan Adrian Priego Parra, Department of Digestive Physiology and Gastrointestinal Motility, Institute of Medical-Biological Research, Universidad Veracruzana, Veracruz 91700, Veracruz, Mexico
Bryan Adrian Priego Parra, Center for Biomedical Research, Universidad Veracruzana, Xalapa 91190, Veracruz, Mexico
Author contributions: Tornel Avelar AI and Priego Parra BA conceptualized the manuscript; Priego Parra BA was responsible for the submission; all the authors contributed to writing and editing, and approved the final version to publish.
Supported by Mexican Association of Gastroenterology 2023 for the scholarship warded.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bryan Adrian Priego Parra, MD, PhD, Department of Digestive Physiology and Gastrointestinal Motility, Institute of Medical-Biological Research, Universidad Veracruzana, Iturbide S/N Entre Carmen Serdán y 20 de Noviembre, Col. Flores Magón, Veracruz 91700, Veracruz, Mexico. bryanpriegop@gmail.com
Received: April 9, 2025
Revised: May 24, 2025
Accepted: July 4, 2025
Published online: July 28, 2025
Processing time: 106 Days and 3.1 Hours
Core Tip

Core Tip: Phospholipase D2 is a key enzyme involved in the hydrolysis of phospholipids. It has been implicated in processes, such as neutrophil migration, the inflammatory response, apoptosis, cell migration, and adhesion in various pathologies. This letter to the editor analyzes multiple research sources on phospholipase D2 in pancreatic conditions, including acute pancreatitis, chronic pancreatitis, and pancreatic cancer. It also highlights the need for future research to consider sex differences in the expression of this enzyme and to evaluate its applicability in clinical practice.