miR-10a-5p and miR-10b-5p restore colonic motility in aged mice

doi:10.3748/wjg.v31.i24.104437

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Jun 28, 2025 (publication date) through Jun 26, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Jun 28, 2025; 31(24): 104437
Published online Jun 28, 2025. doi: 10.3748/wjg.v31.i24.104437

miR-10a-5p and miR-10b-5p restore colonic motility in aged mice

Gain Baek, Rajan Singh, Se Eun Ha, Hayeong Cho, Sesh Padmanabhan, Vachan Vishwanath, Min Seob Kim, Dahyun Seon, Jisong You, Moon Young Lee, Seungil Ro

Gain Baek, Rajan Singh, Se Eun Ha, Hayeong Cho, Sesh Padmanabhan, Vachan Vishwanath, Seungil Ro, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, United States

Min Seob Kim, Dahyun Seon, Jisong You, Moon Young Lee, Department of Physiology, Wonkwang University, Iksan 54538, South Korea

Co-first authors: Gain Baek and Rajan Singh.

Author contributions: Baek G, Singh R, Ha SE, and Ro S conception or design; Baek G, Singh R, Ha SE, Cho H, Padmanabhan S, Vishwanath V, Kim MS, Seon D, You J and Lee MY analysis, or interpretation of data; Baek G, Singh R and Ha SE drafting the work; Ro S revising; All authors have read and agreed to the published version of the manuscript.

Supported by National Institutes of Health Grants, No. R01DK103055 (to Ro S); RosVivo Therapeutics, No. AWD-01-00003158 (to Ro S); and the National Research Foundation of Korea Grant Funded by the Korean Government (MSIT), No. NRF-2021R1C1C2006743 (to Kim MS) and No. NRF-2021R1A2C1095311 (to Lee MY).

Institutional review board statement: Informed consent was obtained from all participants, and the study protocol was approved by the Wonkwang University Institutional Review Board, No. WKIRB-201906-BR-046.

Institutional animal care and use committee statement: All processes involving animal subjects were approved by the Institutional Animal Care and Use Committee at University of Nevada, Reno, which is fully accredited by the American Association for Accreditation of Laboratory Animal Care International, No. 20-05-1007-1.

Conflict-of-interest statement: This author discloses the following: Ro S and the University of Nevada Reno Office of Technology Transfer (serial No. 62/837,988, filed 24 April 2019) have published a PCT International Patent WO/2020/219872 entitled “Methods and compositions of miR-10 mimics and targets thereof”. Ro S is an employee and a member of the board of directors of RosVivo Therapeutics. Ha SE and Singh R are members of the board of directors of RosVivo Therapeutics. The remaining authors disclose no conflicts.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Seungil Ro, PhD, Professor, Department of Physiology and Cell Biology, University of Nevada School of Medicine, Center for Molecular Medicine L-207E, 1664 North Virginia Street, Reno, NV 89557, United States. sro@med.unr.edu

Revised: March 18, 2025
Accepted: June 3, 2025
Published online: June 28, 2025
Processing time: 188 Days and 12.6 Hours

Core Tip

Core Tip: Gastrointestinal (GI) dysmotility is strongly associated with aging, driven by functional changes in the gut. We previously identified miR-10b-5p as a key regulator of GI motility disorders. However, the specific roles of miR-10a-5p and miR-10b-5p in age-related GI dysmotility remain unexplored. This study presents compelling evidence supporting the miR-10a-5p and miR-10b-5p as critical regulators of interstitial cells of Cajal growth and function, playing essential roles in maintaining GI motility in aged mice and humans. Restoration of these microRNAs through miR-10a-5p and miR-10b-5p mimics in aged mice effectively alleviated GI dysmotility, particularly constipation, offering a promising therapeutic strategy for age-related GI motility disorders.