Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2025; 31(20): 105269
Published online May 28, 2025. doi: 10.3748/wjg.v31.i20.105269
Nonlinear association between estimated plasma volume status and acute kidney injury in acute pancreatitis patients
Wen Wu, Yu-Pei Zhang, Yi-Lan Zhang, Xing-Guang Qu, Zhao-Hui Zhang, Rong Zhang, Zhi-Yong Peng
Wen Wu, Yu-Pei Zhang, Yi-Lan Zhang, Xing-Guang Qu, Zhao-Hui Zhang, Rong Zhang, Department of Emergency and Critical Care Medicine, Yichang Central People’s Hospital, Yichang 443000, Hubei Province, China
Wen Wu, Yu-Pei Zhang, Yi-Lan Zhang, Xing-Guang Qu, Zhao-Hui Zhang, Rong Zhang, The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, Hubei Province, China
Wen Wu, Zhi-Yong Peng, Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Wen Wu, Zhi-Yong Peng, Clinical Research Center of Hubei Critical Care Medicine, Wuhan 430071, Hubei Province, China
Co-corresponding authors: Rong Zhang and Zhi-Yong Peng.
Author contributions: Wu W and Zhang YP conceived, designed the study and obtained the data, which was analyzed by Wu W; Zhang YP, Zhang YL, Qing XG and Zhang ZH interpreted the data and results and drafted the manuscript; Zhang R and Peng ZY critically revised the manuscript for intellectual content; All authors were responsible for interpretation of data and for approving the draft manuscript.
Institutional review board statement: The present retrospective study was approved by the Ethics Committee of Yichang Central People’s Hospital, (ethical approval number: 2023-130-01), and performed following Declaration of Helsinki.
Informed consent statement: Informed consent was waived because of the retrospective nature of the study and the analysis used de-identified data.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: Data is available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong Zhang, MD, Doctor, Department of Emergency and Critical Care Medicine, Yichang Central People’s Hospital, No. 183 Yiling Avenue, Wujiagang District, Yichang 443000, Hubei Province, China. zhangrong20240304@163.com
Received: January 18, 2025
Revised: April 18, 2025
Accepted: May 12, 2025
Published online: May 28, 2025
Processing time: 131 Days and 23 Hours
Core Tip

Core Tip: This study is the largest to date examining acute kidney injury (AKI) in patients with acute pancreatitis (AP), and it is the first to explore the association between estimated plasma volume status (ePVS) and the incidence of AKI. The study utilized two formulas (Duarte and Kaplan-Hakim) to assess ePVS and its relationship with AKI risk. Through smooth curve fitting analysis, the results revealed a nonlinear relationship between ePVS and AKI risk, including U-shaped and J-shaped curves. These findings provide important reference for the prediction and management of AKI in patients with AP.